In Yamada-kun and the Seven Witches, Ryuu Yamada enters Suzaku High School hoping to leave behind his violent delinquent reputation and start over. By the time he reaches his second year, though, he has fallen back into bad habits: his grades are terrible, he is lazy, and he keeps getting into fights.
Everything changes when Ryuu meets Urara Shiraishi, a beautiful honors student, and the two accidentally tumble down the stairs and share an unexpected kiss. That slip reveals a strange ability: the pair can switch bodies with a kiss, a power that proves both useful and troublesome as they try to understand it.
Soon afterward, Toranosuke Miyamura, a student council officer and the sole member of the Supernatural Studies Club, recruits them. The club is later joined by Miyabi Itou, an eccentric student fascinated by the supernatural, and together they begin unraveling the legend of the Seven Witches of Suzaku High, seven girls who possess different powers activated by a kiss. Their search pulls Ryuu deeper into a school life stranger than he ever imagined.