Owari no Seraph opens in a world where a mysterious virus wipes out everyone older than 13, leaving only children behind as vampire clans emerge from hiding and seize control of the ruins. In exchange for protection, the vampires demand human blood, turning survival itself into a bargain. At the center of this collapse are Yuuichirou and Mikaela Hyakuya, two boys who grow up in captivity with the other children they treat as family, clinging to one another as the world closes in around them.
After an escape attempt tears their lives apart, Yuuichirou is taken in by the Moon Demon Company, a military unit devoted to exterminating vampires in Japan, and later joins the Japanese Imperial Demon Army. As he fights alongside his new allies, he is forced to balance revenge, loyalty, and the haunting bonds that tie him to the people he left behind.
Mixing post-apocalyptic action, supernatural warfare, and emotional conflict, Owari no Seraph follows children forced to inherit the ruins of humanity, where every victory against the vampires carries a painful cost.