In Tetsuwan Birdy DECODE, Birdy Cephon Altera, a bombastic police officer from the Space Federation, arrives on Earth while pursuing the alien fugitive Geega. Because her target has disguised himself as a human and assimilated into the fashion industry, Birdy follows suit, joins a modeling agency, and assumes the identity "Shion Arita." As Shion, she spends her days posing for photo shoots as a rising model and her nights tracking intergalactic criminals.
At the same time, Tsutomu Senkawa, an average high school student, explores an abandoned building with his friend and happens to cross paths with Birdy's hunt for Geega. Senkawa briefly witnesses their battle before Geega seizes him as a hostage. Birdy, unaware of what has happened, attacks Geega and accidentally kills Senkawa. Horrified by the mistake, she chooses the only way to save him: integrating his consciousness into her own body.
Forced to cohabit a single body, Birdy and Senkawa must navigate an uneasy shared life while juggling Senkawa's high school routine, Shion Arita's modeling career, and Birdy's increasingly dangerous duties as a Federation officer.