Sakura Trick follows Haruka Takayama and Yuu Sonoda, two inseparable middle school friends who enter Misato West High School determined to stay side by side. Their plan immediately runs into trouble when they are assigned to the same class but end up sitting at opposite ends of the classroom, and the situation feels even more fragile because their school will shut down in three years, leaving them as the final intake of first-year students. For Haruka, those limited days become precious, and she throws herself into making unforgettable memories with Yuu before their everyday life changes forever.
Yuu's easygoing personality quickly draws the attention of their female classmates, stirring Haruka's jealousy and making both girls confront feelings they have long kept unspoken. In an empty classroom, Yuu answers that insecurity with a deep, affectionate kiss that transforms their bond into something more intimate than ordinary friendship. From that moment on, Sakura Trick traces the awkward, sweet, and sometimes conflicting emotions that follow as the two girls try to understand their growing attachment while holding on to the closeness that has defined them for years.