Killing Bites thrusts college student Yuuya Nomoto into a nightmare after he is dragged into a kidnapping, forced to drive Hitomi Uzaki—the high school girl his friends tried to abduct—to an undisclosed location, and trapped in a death match he never understood. He watches the men around him die brutally before realizing he has become the prize in a fight between Therianthropes, superpowered human-animal hybrids created through advanced gene therapy. As one of these hybrids, Hitomi channels the speed and fearlessness granted by her ratel genes to crush her opponent and pull Yuuya back from certain death.
Hours later, Yuuya wakes up hoping the ordeal was only a nightmare, but the truth is far worse: he has been pulled into a secret proxy war between four major Japanese business conglomerates, with the winner set to control the economy. As Hitomi's sole, unwilling investor, his fate is tied to her survival and to every underground bloodsport match known as Killing Bites. Together, they are forced to navigate a world where profit, power, and predation are inseparable, and where every victory only deepens the reach of the organizations controlling the contest from behind the scenes.