Zetman follows two rival heroes, ZET and ALPHAS, whose clashes begin before their origins are fully revealed. Jin Kanzaki is a young man able to transform into the superhuman ZET, while Kouga Amagi fights with technology as ALPHAS and carries a strong sense of justice. Their lives move toward the same conflict as they protect mankind from the monstrous Players.
Behind that battle lies the Amagi Corporation, founded by Kouga's grandfather Mitsugai Amagi, and the experiments that created the Players in the first place. As Jin and Kouga face enemies both human and inhuman, the people around them are drawn into the struggle, and the rivalry between the two heroes becomes a fight over what it means to save the world.