Strawberry Panic! follows Nagisa Aoi as she begins her new school life after transferring to St. Miator’s Girls Academy, one of three prestigious all-girls schools on Astraea Hill. On her first day, Nagisa gets lost on the campus and encounters a mysterious student whose elegance and charm are so overwhelming that the meeting ends with Nagisa in the infirmary.
When she wakes up, her roommate, Tamao Suzumi, introduces her to the routines, hierarchy, and unspoken rules of life at St. Miator. Tamao also explains the Etoile, the extraordinary student representative chosen from among the three schools and celebrated as the "star" of Astraea Hill. Nagisa soon discovers that the ethereal girl she met is Shizuma Hanazono, the current Etoile, and Shizuma’s open interest in her quickly makes Nagisa the center of attention.
As Nagisa, Shizuma, Tamao, and their friends move between St. Miator’s, St. Spica, and St. Lulim, Strawberry Panic! explores the emotional bonds, hidden feelings, lingering regrets, and uncertain possibilities that shape everyday life on Astraea Hill.