In World's End Harem, Tokyo medical student Reito Mizuhara learns that he has cellular sclerosis, a rare and fatal illness, and is placed into cryogenic sleep to survive. Five years later he wakes to a world that has been transformed beyond recognition: while he slept, the Male Killer (MK) virus swept across the globe, killed every other man on Earth, and left humanity on the edge of extinction.
Reito is not alone. He is one of only five men spared because they were in cryosleep, and all five are immune. With the future of the species now tied to them, they are expected to father the next generation and help repopulate the planet, each reacting to that burden in different ways. Reito, however, cannot let go of his childhood friend and sole love interest, Elisa Tachibana. Even after learning that she disappeared three years earlier, he sets out to find her, push back against the pressure surrounding him, and uncover the truth behind the virus. In a world where survival, temptation, and uncertainty constantly collide, every choice carries a cost.