Satsuriku no Tenshi takes place inside a sealed, abandoned building where 13-year-old Rachel Gardner wakes in the basement with dead, lifeless eyes and a single wish: to die. She has no idea how or why she was brought there, and every floor is controlled by a different killer. While searching for a way out, she stumbles across a bandaged murderer named Zack—Isaac Foster—who is trying to escape the same nightmare. The two make a grim promise: if Zack helps her reach the surface, he will kill her once he is free.
Rachel and Zack begin ascending floor by floor, facing a new boss on each level as they move through the building. The people waiting above are twisted, violent, and strangely familiar with Rachel, hinting at a deeper connection between her and the place that imprisons them. As her eerie calm collides with Zack's brutal impatience, their uneasy partnership drives a claustrophobic survival story built on mutual need, broken morality, and the mystery of why Rachel was placed there at all. Whether either of them can truly achieve their wish remains at the heart of their escape.