Reign of the Seven Spellblades opens at Kimberly Magic Academy, where survival matters as much as spellcraft and only four out of five students are expected to make it to graduation in one piece. Impressed by Nanao Hibiya's skill with a sword, Kimberly instructor Theodore McFarlane saves the samurai from certain death amid a fierce battle, and his encouragement leads her to enroll at the academy. There, Nanao quickly becomes a celebrity after she and four of her peers save a student from an enraged troll, drawing attention to the dangerous world hidden behind Kimberly's polished walls.
Under the leadership of Oliver Horn, a young man who seems to hide a troubled past, Nanao and her newfound friends begin their magical apprenticeship at Kimberly. Their early days soon take a darker turn when a near-death encounter in the labyrinth under the school forces Nanao to confront her bloody past. As the mysteries of the academy deepen, the inexperienced yet determined students must stick together if they want any chance of surviving long enough to uncover the truth behind Kimberly's dangers.