Mononoke follows the enigmatic Medicine Seller as he travels through feudal Japan, arriving wherever a vengeful spirit or a gathering of human fears has twisted the world around it. He does not exorcise mononoke by force alone: before he can draw the Exorcism Sword, he must uncover each spirit's Form, Truth, and Reason. That ritual turns every case into a confrontation with buried guilt, grief, and the lies people tell to survive.
Across its eerie, self-contained mysteries, Mononoke builds a portrait of a country haunted as much by human desire as by supernatural malice. The Medicine Seller slips into temples, inns, and remote villages, reading the atmosphere, testing witnesses, and piecing together the emotional logic that gives a spirit power. One of those cases leads him to an old-fashioned inn where Shino, a pregnant woman, has finally found a place to rest. The owner reluctantly offers her the last vacant room, but the Medicine Seller senses that the room is haunted by a lethal band of mononoke, the Zashiki Warashi. As he works to uncover the Form, the Truth, and the Reason behind the haunting before the Zashiki Warashi can kill again, the series blends occult investigation, psychological tension, and ornate visual style into a supernatural mystery built on what people hide rather than what they openly reveal.