In Kiss x Sis, Keita Suminoe's life changes after his mother dies and his father remarries, bringing twin step-sisters Ako and Riko into the household. From their first meeting, both girls develop an intense affection for their younger brother, and what begins as a family arrangement quickly turns into a constant struggle for Keita's attention and composure.
As Keita reaches the end of middle school, he studies hard so he can enter the same high school as Ako and Riko, hoping to stay close to them while sorting through his own confusing feelings about his new family. Caught between rejecting and yielding to his sisters' increasingly intimate advances, he also has to deal with other girls who show interest in him, making everyday life an unpredictable battle against temptation. Balancing embarrassment, attachment, and awkward romance, Keita is forced to navigate a household where affection and conflict are never far apart.