Isekai Yakkyoku follows Kanji Yakutani, a world-class medical researcher who never stopped chasing better medicines after losing his little sister to a tumor years earlier, when treatment failed to save her. Burdened by that memory, he spends his life trying to create cures that could prevent the same tragedy from happening to anyone else, only to die at 31 from overworking himself and be given a second chance in another world.
He awakens as Falma de Médicis, a 10-year-old boy born into an esteemed family of medical practitioners in the Sain Fleuve Empire. Blessed by a deity, Falma gains a unique divine art that lets him create and reduce any substance, as long as he understands its chemical properties. With that power and the knowledge he carried from his former life, he quickly realizes how primitive medicine remains in this world, where treatment is still rooted in ancient practices and proper care is reserved for the nobility.
As Falma studies pharmacology books and sees how completely commoners are excluded from effective treatment, he decides to challenge the system from within. Using both modern medical knowledge and his divine abilities, he works to reform the empire's approach to healing and make medicine available to everyone, regardless of class.