Haite Kudasai, Takamine-san follows mild-mannered Koushi Shirota after he witnesses the immaculate student council president, Takane Takamine, brazenly strip off her panties in front of the entire class after receiving an uncharacteristic test score of 98%. Before he can dismiss the scene as a hallucination, the score suddenly changes to a perfect 100% right before his eyes, forcing him to confront Takamine about what he saw.
Takamine then reveals the secret behind her flawless reputation: an ability called Eternal Virgin Road, which lets her undo any mistake by taking off a piece of underwear, preserving her prodigious facade at all costs. With Shirota as the only person aware of the truth, she coerces him into becoming her closet—a carrier of spare panties—so she can use Eternal Virgin Road as many times as she wants.
From that point on, Shirota is dragged into Takamine's increasingly chaotic routine, where every mishap can trigger another embarrassing wardrobe change and every favor keeps him trapped between leverage, secrecy, and far-too-close encounters with the student council president. As her unpredictable demands continue, his ordinary school life becomes a nonstop battle to survive her impossible secret.