Devil May Cry follows Dante, the owner of the odd-jobs business Devil May Cry, whose lazy, careless attitude hides a sharp talent for hunting demons. When J.D. Morrison brings Patty Lowell, a girl found at an orphanage and revealed to be the lost heir of a prestigious family, Dante agrees to act as her bodyguard and escort her to her relatives, even if he treats the assignment like a nuisance at first. The job quickly proves more dangerous than a simple babysitting run, because demons begin pursuing Patty and it becomes clear that someone or something wants her before she can reach home.
As Dante keeps Patty safe, the story leans on the contrast between his laid-back demeanor and the ruthless efficiency he shows when the situation turns violent. Morrison's involvement, Patty's uncertain place in the middle of a family mystery, and the constant demon attacks turn the journey into more than a single protection detail: it becomes a test of Dante's instincts, his professionalism, and the strange network of people who rely on him when the supernatural breaks into everyday life.