Arknights is set in Terra, a world shaped by Originium, a black crystalline mineral that powers advanced technology and the mysterious Arts, but also fuels Catastrophes, devastating disasters that leave new deposits behind and spread the lethal, highly contagious disease Oripathy. As the infected face growing discrimination, cities and governments respond with fear and repression, turning a medical crisis into a political one.
In the middle of that unrest stands Rhodes Island, a paramilitary pharmaceutical organization committed to treating infected and uninfected people as equals while searching for an Oripathy cure. Its efforts are constantly complicated by Reunion, a violent rebel faction that channels the anger of the infected into attacks on the very systems that have abandoned them. Rhodes Island depends on the strategies of the enigmatic Doctor, whose amnesia has left them with fragments of a past that may prove crucial to the organization's mission. Across Terra, survival, medicine, and power are inseparable, and every decision shapes the future of those caught between catastrophe and rebellion.